Lipids,Structure and Function of Membrane Proteins, G-protein Receptor, Rhodopsin

Biogenesis and Function of Mitochondrial Membrane Proteins

Protein Structure and Folding, NMR Spectroscopy.

Proteomics and Metabolomics, Mass Spectrometry

Drug Discovery, Chemical Ecology

Ubiquitin-Proteasomal Pathway in Cancer, NMR Spectroscopy, X-ray Crystallography.

Structure Function Relationships in Rhodopsin and the Cone Pigments

Lyme Disease/Borrelia burgdorferi 

Innate Immunity Pathway for Defense Against Viral Infection, Analytical Ultracentrifugation, SAXS

Biophysics Facility

Structure and Function of Biological Pigments and Pigment-protein Complexes, Ultrafast Time-resolved Optical Spectroscopy, EPR

Quantum Mechanics/Molecular Mechanics Methods in Bio-macromolecules, Structural and Electronic Properties of Protein Active Sites, Computational Modeling, Monolayer Protected Nanoparticles.

NMR spectroscopy, Data Processing and Reproducibility

Medicinal Chemistry, Chemical Biology, Cancer and Neurodegenerative Disorders

Ubiquitin E3 Ligases Altered in Cancer, Spore Germination Receptors, X-ray Crystallography

NMR Spectroscopy, NMR Data Acquisition and Processing, Reproducible Computing for Bio-NMR, Director of Gregory P. Mullen NMR Structural Biology Facility,
Director of NMRbox: National Center for Biomolecular NMR Data Processing and Analysis

Nano-bio Mechanical Systems, Analysis and Design of Mechanisms, Machines and Gear Systems, Robotics, Analytical and Computational Kinematics, Design Optimization

Biochemical and Biophysical Analyses of Membrane-interactive Proteins, Cannabinoid Receptor Activation and Signal Transduction, Allosteric Modulation of GPCRs

Molecular Motors, Cilia, Peptide Amidation, Electron Microscopy, NMR Spectroscopy, Director of UConn Health Central Electron Microscopy Facility

DNA Replication and Repair, Protein Structure and Dynamics, NMR Spectroscopy, X-ray Crystallography.

NMR Spectroscopy, Protein Structure, Dynamics, and Interactions, Advanced Data Collection and Data Processing, NMRbox

Computational Structural Virology, Molecular Modeling, Non-enveloped Virus Cell Entry, Mitochondrial Membrane Morphology

Protein Small Molecule Interactions, Natural Product-like Small Molecules, Antibiotics

Lyme Disease/Borrelia burgdorferi, Syphilis/Treponema pallidum, Membrane Proteins

Stress and Cellular Survival, Structural and Biochemical Properties of Prokaryotic GTPases, X-ray Crystallography, SAXS

Modeling of Protein Dynamics and Molecular Interactions,  Allostery,  Development of Nonuniform Sampling Approaches for multidimensional NMR, NMRbox

Spores of Bacteria of Bacillus Species, Spore Resistance and Germination, Germination Receptors

Systems Biology, Metabolic Engineering, Evolutionary Algorithms, Computational Biology, Tool Development

Fundamental Mechanisms of Protein Assembly, Virus Assembly, Bacterial Secretion

Protein-protein Interactions,  Membrane Proteins, Across-membrane Signal Transduction, NMR Spectrocopy

Mechanisms of Synthesis, Maturation, Cleavage and Packaging of Viral Genomes, HSV-1, Anti-viral Drug Discovery

Assembly of RNA viruses, Picornaviridae,  Cryo-electron Microscopy, Cell Biology, and Single Molecule Biophysics

Medicinal Chemistry, Structure-based Drug Design, Bioactive Natural Products, Small Molecule Library Design and Screening

Mass Spectrometry and Omic Chemistry

Critical Problems of Membrane Protein Structure